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FLASH GENE
Symbol SNX6 contributors: mct - updated : 13-06-2013
HGNC name sorting nexin 6
HGNC id 14970
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Digestiveesophagus   highly
 liver   highly
Endocrineparathyroid   predominantly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
 nervecranial nerve  highly
Reproductivefemale systemplacenta  highly
Respiratorylung   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phox (PX) homology domain
  • a Vps5 domain
    • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to C.elegans Y59A8B.22
    homolog to rattus Snx6 (99.51 pc)
    homolog to murine Snx6 (99.51 pc)
    intraspecies homolog to SNX5
    Homologene
    FAMILY
  • sorting nexin family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text colocalised with SNX1 and SNX5 on early endosomes
    basic FUNCTION
  • involved in several stage of intracellular trafficking
  • inhibiting Na/K-ATPase-suppressive activity of TPT1
  • SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates
  • increases BRMS1-dependent transcriptional repression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text receptor trafficking
    PATHWAY
    metabolism
    signaling
    a component component of the retromer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TGFB receptors
  • ACVR2B and others SNX
  • TPT1
  • interaction SNX6-DCTN1 for recruitment of the motor complex to the membrane-associated retromer
  • association of SNX6 with breast cancer metastasis suppressor 1 (BRMS1) protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS