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FLASH GENE
Symbol SNX6 contributors: mct - updated : 13-06-2013
HGNC name sorting nexin 6
HGNC id 14970
DNA
TYPE functioning gene
STRUCTURE 68.45 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
EGLN3 14q12 egl nine homolog 3 (C. elegans) C14orf147 14q13.1 chromosome 14 open reading frame 147 LOC122585 14q13.1 similar to 60S ribosomal protein L23a C14orf11 14q13 chromosome 14 open reading frame 11 SNX6 14q12 sorting nexin 6 LOC390465 14 similar to 60S ribosomal protein L23a CFL2 14q12-q13 cofilin 2 (muscle) LOC387982 14 similar to 60S RIBOSOMAL PROTEIN L12 BAZ1A 14q12-q13 bromodomain adjacent to zinc finger domain, 1A LOC390466 14 similar to SMT3 suppressor of mif two 3 homolog 2 LOC338902 14q13.2 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) SRP54 14q12-q13 signal recognition particle 54kDa C14orf24 14q13.2 chromosome 14 open reading frame 24 C14orf10 14q12 chromosome 14 open reading frame 10 KIAA0391 14q13.1-q21.2 chromosome 14 open reading frame 10 CDC10P 14 CDC10 cell division cycle 10 homolog (S. cerevisiae) pseudogene MRP63P8 14q13.2 mitochondrial ribosomal protein 63 pseudogene 8 PSMA6 14q13 proteasome (prosome, macropain) subunit, alpha type, 6 LOC122589 14q13.2 similar to 60S acidic ribosomal protein P0 (L10E) NFKBIA 14q13 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha DNAJC8P1 14 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1 LOC387983 14 LOC387983 LOC390467 14 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC122592 14q13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) INSM2 14q13.1 insulinoma-associated 2 LOC387984 14 similar to GARNL1 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 splicing 3080 - 290 - 2001 11279102
  • containing exon 2a (longer than 2b)
  • lacking exon 1
  • 14 splicing 2975 47.67 418 - 2001 11279102
  • containing exon 2b (shorter than 2a)
  • encoding for the longest product
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     liver   highly
    Endocrineparathyroid   predominantly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
     nervecranial nerve  highly
    Reproductivefemale systemplacenta  highly
    Respiratorylung   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phox (PX) homology domain
  • a Vps5 domain
  • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to C.elegans Y59A8B.22
    homolog to rattus Snx6 (99.51 pc)
    homolog to murine Snx6 (99.51 pc)
    intraspecies homolog to SNX5
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text colocalised with SNX1 and SNX5 on early endosomes
    basic FUNCTION
  • involved in several stage of intracellular trafficking
  • inhibiting Na/K-ATPase-suppressive activity of TPT1
  • SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates
  • increases BRMS1-dependent transcriptional repression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text receptor trafficking
    PATHWAY
    metabolism
    signaling
    a component component of the retromer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TGFB receptors
  • ACVR2B and others SNX
  • TPT1
  • interaction SNX6-DCTN1 for recruitment of the motor complex to the membrane-associated retromer
  • association of SNX6 with breast cancer metastasis suppressor 1 (BRMS1) protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS