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FLASH GENE

Symbol

RPS2

contributors: mct - updated : 05-12-2023

HGNC name	ribosomal protein S2
HGNC id	10404

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002952 7 - 945 NP_002943 - 293 - 2020 33245768

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Lymphoid/Immune tonsils       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two ribosomal S5 domains
	a N-terminal Arg-Gly repeat as the methylation site
	a central domain comprising 72 amino acids which is necessary and sufficient to target the chimeric beta-galactosidase to the nucleus

mono polymer

heteromer

HOMOLOGY

interspecies	homolog to murine llrep3
	homolog to C.elegans c49h3.11

Homologene

FAMILY

S5P family

CATEGORY

chaperone/stress , RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm
text	in the nucleus, strictly localized in the nucleoplasm and not targeted to the nucleoli

basic FUNCTION	40S ribosomal protein S2
	nuclear uptake could be mediated by several import receptors since it binds to importinalpha/beta and transportin
	RPS2 plays likely a critical role in the regulation of TP53 signaling including the ribosomal stress response

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the small 40S ribosomal subunit
	RPS2 promotes likely the formation of a conserved extraribosomal complex with PRMT3 and PDCD2L

INTERACTION

DNA

RNA

binding

small molecule

protein	substrate for PRMT3 (methylated by PRMT3 )
	Tyr87 is important for the interaction between PRMT3 and RPS2 and for its full enzymatic activity
	PDCD2 interacts with RPS2 connecting ribosome maturation and gene-specific translation
	ZNF277 recognizes nascent RPS2 in the course of mRNA translation, suggesting cotranslational assembly of the ZNF277-RPS2 complex
	ZNF277 and PRMT3 compete for RPS2 binding, because overexpression of PRMT3 inhibited the formation of the ZNF277-RPS2 complex
	RPS2 interacts with MDM2 through the RING finger domain of MDM2, and RPS2 is ubiquitinated by MDM2 and the ubiquitinated status of RPS2 regulates the stability of TP53
	PDCD2 specifically interacts with the 40S ribosomal protein uS5 (RPS2)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS