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FLASH GENE

Symbol

RPS2

contributors: - updated : 04-11-2006

HGNC name	ribosomal protein S2
HGNC id	10404

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Lymphoid/Immune tonsils       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two ribosomal S5 domains
	a N-terminal Arg-Gly repeat as the methylation site
	a central domain comprising 72 amino acids which is necessary and sufficient to target the chimeric beta-galactosidase to the nucleus

mono polymer

heteromer

HOMOLOGY

interspecies	homolog to murine llrep3
	homolog to C.elegans c49h3.11

Homologene

FAMILY

S5P family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm
text	in the nucleus, strictly localized in the nucleoplasm and not targeted to the nucleoli

basic FUNCTION	40S ribosomal protein S2
	nuclear uptake could be mediated by several import receptors since it binds to importinalpha/beta and transportin

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the small 40S ribosomal subunit

INTERACTION

DNA

RNA

binding

small molecule

protein

substrate for PRMT3 (methylated by PRMT3 )

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS