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FLASH GENE
Symbol RPS2 contributors: - updated : 04-11-2006
HGNC name ribosomal protein S2
HGNC id 10404
Location 16p13.3      Physical location : 2.012.061 - 2.014.827
Synonym name 40s ribosomal protein s2
Synonym symbol(s) LLREP3
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunetonsils   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ribosomal S5 domains
  • a N-terminal Arg-Gly repeat as the methylation site
  • a central domain comprising 72 amino acids which is necessary and sufficient to target the chimeric beta-galactosidase to the nucleus
    • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to murine llrep3
    homolog to C.elegans c49h3.11
    Homologene
    FAMILY S5P family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    text in the nucleus, strictly localized in the nucleoplasm and not targeted to the nucleoli
    basic FUNCTION
  • 40S ribosomal protein S2
  • nuclear uptake could be mediated by several import receptors since it binds to importinalpha/beta and transportin
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the small 40S ribosomal subunit
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein substrate for PRMT3 (methylated by PRMT3 )
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS