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FLASH GENE
Symbol NAA10 contributors: mct - updated : 28-04-2017
HGNC name N(alpha)-acetyltransferase 10, NatA catalytic subunit
HGNC id 18704
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1091 - 220 - 2015 25421966
8 - 1118 - 229 - 2015 25421966
8 - 1136 - 235 primarily localized in the cytoplasm 2015 25421966
- - - - 131 was mostly localized in the cell nucleus 2015 25421966
  • possesses an altered reading frame due to a 46-bp deletion
  • autoacetylation activity was absent
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Endocrineadrenal gland   highly
     neuroendocrinepituitary  highly
     pancreas   highly
    Nervousbrain     Homo sapiensFetal
    Reproductivefemale systemuteruscervix highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-acetyltransferase domain
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae ard1 N-acetyltransferase
    homolog to murine Ard1
    homolog to Drosophila CG11989
    homolog to C.elegans K07H8.3
    Homologene
    FAMILY
  • acetyltransferase family
  • ARD1 subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text
  • is imported to the nuclei of proliferating cells, especially during S phase
  • NAA10 and NAA15 are both highly expressed in regions of cell division and migration during brain development
    • basic FUNCTION
  • playing a role on DNA packaging (chromosome organization and biogenesis)
  • involved in N-acetylation
  • might play an important role in breast cancer carcinogenesis
  • is involved in controlling cell proliferation, apoptosis, autophagy and neuronal development
  • its nuclear translocation mediated by NLS is required for cell cycle progression, thereby contributing to proper cell proliferation
  • acts as a guard ensuring balanced osteogenesis by fine-tuning RUNX2 signalling in a feedback manner
  • displays alpha (N-terminal) acetyltransferase activity
  • functions as a major modulator of cell growth and differentiation
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with NARG1, displaying alpha (N-terminal) acetyltransferase activity
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with HIF1A
  • interacts with NARG1 and with the ribosome
  • NAA15 associates with the acetyltransferase NAA10 and exerts an angiostatic function in adult retinal-blood-vessel homeostasis
  • HIF1A was found to inactivate the Wnt signaling by binding to NAA10 or beta-catenin, which may contribute to the hypoxia-induced growth arrest of tumor cells
  • is an oncoprotein, but it contributes to oncogenesis through modulation of DNMT1 function
  • NAA10 positively regulated MCL1 expression, as exogenous NAA10 promoted MCL1 expression, whereas NAA10 silencing decreased MCL1 expression
  • NAA10 inhibits apoptosis through NAA10-RELA-dependent MCL1 transcriptional activation
  • NAA10 suppresses 28S proteasome activity through interaction with PSME2
  • inhibits the metastasis of breast cancer cells by targeting STAT5A
  • new NAA10 function in RUNX2-mediated osteogenesis
  • may acetylate lysine residues of diverse targets, including methionine sulfoxide reductase A, myosin light chain kinase, and RUNX2
    • cell & other
    REGULATION
    Phosphorylated by IKBKB (IKBKB physically associated with NAA10 and phosphorylated it at Ser209)
    Other cleaved by caspases during apoptosis
    negative regulation of NAA10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s) NATD , MCOPS1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    NAA10 inhibition could be considered a potential strategy for facilitating bone formation
    ANIMAL & CELL MODELS