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FLASH GENE
Symbol RAPGEF1 contributors: mct/ - updated : 06-03-2007
HGNC name Rap guanine nucleotide exchange factor (GEF) 1
HGNC id 4568
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 6121 135 1077 - PMID: 14551197
24 - 6204 122.6 1095 - PMID: 14551197
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
Reproductivefemale systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RAS-GEF domain
  • SH3 biding region in a proline-rich domain
  • Src homology 2 (SH2) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text recruited to the cholesterol enriched microdomains (lipid rafts) in association with CRK
    basic FUNCTION
  • guanine nucleotide releasing factor 2 for Rap 1 playing a role in CRK signaling pathways
  • role for RAP1A and its exchange factor RAPGEF1 in mediating Fc gammaR-dependent phagocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    transducing signals from RTKs to activate RAS, insulin signaling pathway
    a component
  • forming a complex with CRK
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CRK and GRB2 SH3 domains
  • activating TC10 in lipid raft,essential for insulin stimulated glucose uptake and GLUT4 translocation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS