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FLASH GENE
Symbol RAPGEF1 contributors: mct/ - updated : 06-03-2007
HGNC name Rap guanine nucleotide exchange factor (GEF) 1
HGNC id 4568
Location 9q34.13      Physical location : 134.452.157 - 134.612.925
Synonym name
  • guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
  • CRK SH3-binding GNRP
  • protein C3G
    • Synonym symbol(s) C3G, GRF2, DKFZp781P1719
    DNA
    TYPE functioning gene
    STRUCTURE 160.77 kb     24 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 6121 135 1077 - PMID: 14551197
    24 - 6204 122.6 1095 - PMID: 14551197
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RAS-GEF domain
  • SH3 biding region in a proline-rich domain
  • Src homology 2 (SH2) domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text recruited to the cholesterol enriched microdomains (lipid rafts) in association with CRK
    basic FUNCTION
  • guanine nucleotide releasing factor 2 for Rap 1 playing a role in CRK signaling pathways
  • role for RAP1A and its exchange factor RAPGEF1 in mediating Fc gammaR-dependent phagocytosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    transducing signals from RTKs to activate RAS, insulin signaling pathway
    a component
  • forming a complex with CRK
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CRK and GRB2 SH3 domains
  • activating TC10 in lipid raft,essential for insulin stimulated glucose uptake and GLUT4 translocation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS