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FLASH GENE

Symbol

SYF2

contributors: npt - updated : 21-04-2005

HGNC name	SYF2 homolog, RNA splicing factor (S. cerevisiae)
HGNC id	19824

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 1372 isoform 1 29 243 - Chang (00) the longest isoform variant 2 - splicing 1247 isoform 2 - 201 - Chang (00) lacks an in-frame exon in the coding region, resulting in an isoform lacking an internal segment and the two BNLS, compared to isoform 1

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two BNLS (bipartite nuclear localization signal)

HOMOLOGY

Homologene

FAMILY

SYF2 family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

may be involved in cell cycle regulation at the G1/S transition, via its interaction with CCNDBP1

CELLULAR PROCESS	cell cycle, progression

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacting with CCNDBP1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS