basic FUNCTION
| inhibiting endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor |
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being a critical regulator of the signaling pathways that regulate T-cell activation |
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implicated in the regulation of signaling mediated by protein tyrosine kinases (PTKs) |
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with UBASH3A, may exert opposite effects on PTK-mediated signaling |
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multidomain proteins that negatively regulate the signaling of membrane-bound receptors, including TCR and the epidermal growth factor receptor (EGFR) |
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function as critical negative regulators of TCR signaling |
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instrumental in down-modulating proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination |
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has a key role in platelet glycoprotein VI (GPVI) signaling |
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primary tyrosine phosphatase mediating the dephosphorylation of SYK and thus functions as a negative regulator of GP6 signaling in platelets |
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recognizes two distinct classes of Tyr(P) substrates and is highly active toward peptides corresponding to the Tyr(P)-323 and Tyr(P)-352 sites of SYK |
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UBASH3A, UBASH3B function as critical negative regulators of TCR signaling |
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may likely play a role during early as well late stages of osteoclast differentiation, and negatively regulates osteoclast differentiation and function |
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may function as a crucial node in bridging multiple invasion-promoting pathways |
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suppress T-cell-driven inflammatory responses |
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pivotal role of UBASH3A/UBASH3B in regulating hematopoietic stem and progenitor cell fitness |
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is an important regulator of mitosis |
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protein-tyrosine phosphatase that has been shown to regulate receptor signaling in several cell types, including platelets |
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control Spindle Assembly Checkpoint (SAC) silencing and faithful chromosome segregation by relocalizing Aurora B kinase to the mitotic microtubules |