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FLASH GENE

Symbol

PYGB

contributors: - updated : 27-01-2007

HGNC name	phosphorylase, glycogen; brain
HGNC id	9723

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Nervous brain           nerve       highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

glycogen phosphorylase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

catalyzes the rate-determining step in glycogen degradation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase

INTERACTION

DNA

RNA

small molecule	cofactor,
	pyridoxal phosphate

protein

cell & other

REGULATION

activated by

by AMP

inhibited by

ATP, ADP, and glucose-6-phosphate

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS