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FLASH GENE

Symbol

COMMD3

contributors: mct - updated : 14-04-2021

HGNC name	COMM domain containing 3
HGNC id	23332

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012071 8 - 926 NP_036203 - 195 - 2019 31088898

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine parathyroid       highly Lymphoid/Immune lymph node       highly Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

COMM (copper metabolism gene MURR1) domain

HOMOLOGY

interspecies

ortholog to murine Commd3

Homologene

FAMILY

MURR1/COMMD1 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus

basic FUNCTION	having two-component sensor molecule activity
	suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

COMMD3/COMMD8 complex is a specificity determinant of GRK targeting to GPCRs and represents a point of regulation for immune responses

INTERACTION

DNA

RNA

small molecule

protein	COMMD3 and COMMD9 may be endogenous regulators of SCNN1A to regulate Na&
	8314; transport through altering SCNN1A cell surface expression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function deficiency of COMMD3 impaired B cell migration and humoral immune responses tumoral     --low   in several non-small cell lung cancer (NSCLC) cell lines

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS