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FLASH GENE
Symbol COMMD3 contributors: mct - updated : 14-04-2021
HGNC name COMM domain containing 3
HGNC id 23332
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • COMM (copper metabolism gene MURR1) domain
  • HOMOLOGY
    interspecies ortholog to murine Commd3
    Homologene
    FAMILY MURR1/COMMD1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • having two-component sensor molecule activity
  • suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • COMMD3/COMMD8 complex is a specificity determinant of GRK targeting to GPCRs and represents a point of regulation for immune responses
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COMMD3 and COMMD9 may be endogenous regulators of SCNN1A to regulate Na&
  • 8314; transport through altering SCNN1A cell surface expression
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    deficiency of COMMD3 impaired B cell migration and humoral immune responses
    tumoral     --low  
    in several non-small cell lung cancer (NSCLC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS