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FLASH GENE
Symbol SART3 contributors: mct - updated : 17/09/2008
HGNC name squamous cell carcinoma antigen recognized by T cells 3
HGNC id 16860
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4377 109.8 963 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemuteruscervix highly
 male systemtestis   
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines squamous cell carcinoma (head and neck, lung, esophageal), adenocarcinoma
fluid/secretion
at STAGE
physiological period fetal
Text pancreas, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight HAT repeats
  • two C-terminal RNA recognition motif (RRM) domains
  • two nuclear localization signals
  • a putative tyrosine phosphorylation motif
  • an RGD cell attachment sequence
  • conjugated Other
    mono polymer complex
    HOMOLOGY
    interspecies homolog to dog SART3 (91.6 pc)
    homolog to chimpanzee SART3 (99.8 pc)
    homolog to rattus Sart3 (86.8 pc)
    homolog to murine Sart3 (87.3 pc)
    Homologene
    FAMILY
  • RNP ELAV family
  • CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis
  • expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver
  • basic FUNCTION
  • may be involved in the regulation of mRNA splicing
  • required for the proper development and maintenance of neurons presumably by affecting RNA metabolism
  • tumor rejection antigen capable of inducing HLA-24-restricted and tumor specific cytotoxic T lymphocytes
  • could be an appropriate vaccine candidate for specific immunotherapy for colorectal carcinoma patients
  • regulating Tat transactivation activity
  • negative regulator of androgen receptor transcriptional activation and may be directly involved in AR-related developmental, physiological and pathological processes
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs
  • acetylation
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with RNPS1
  • binding to HIV-1 Tat
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    corresponding disease(s) DSAP1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS