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FLASH GENE
Symbol SART3 contributors: mct - updated : 17/09/2008
HGNC name squamous cell carcinoma antigen recognized by T cells 3
HGNC id 16860
Corresponding disease
DSAP1 porokeratosis, disseminated superficial actinic, 1
Location 12q24.1      Physical location : 108.915.990 - 108.955.165
Synonym name
  • Prp24 related protein
  • tat-interacting protein of 110 kDa
    • Synonym symbol(s) TIP110, KIAA0156, p110(nrb), RP11-13G14, P100, p110, DSAP1, MGC138188
    DNA
    TYPE functioning gene
    STRUCTURE 39.20 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4377 109.8 963 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines squamous cell carcinoma (head and neck, lung, esophageal), adenocarcinoma
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight HAT repeats
  • two C-terminal RNA recognition motif (RRM) domains
  • two nuclear localization signals
  • a putative tyrosine phosphorylation motif
  • an RGD cell attachment sequence
    • conjugated Other
    mono polymer complex
    HOMOLOGY
    interspecies homolog to dog SART3 (91.6 pc)
    homolog to chimpanzee SART3 (99.8 pc)
    homolog to rattus Sart3 (86.8 pc)
    homolog to murine Sart3 (87.3 pc)
    Homologene
    FAMILY
  • RNP ELAV family
    • CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis
  • expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver
    • basic FUNCTION
  • may be involved in the regulation of mRNA splicing
  • required for the proper development and maintenance of neurons presumably by affecting RNA metabolism
  • tumor rejection antigen capable of inducing HLA-24-restricted and tumor specific cytotoxic T lymphocytes
  • could be an appropriate vaccine candidate for specific immunotherapy for colorectal carcinoma patients
  • regulating Tat transactivation activity
  • negative regulator of androgen receptor transcriptional activation and may be directly involved in AR-related developmental, physiological and pathological processes
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs
  • acetylation
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with RNPS1
  • binding to HIV-1 Tat
    • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    corresponding disease(s) DSAP1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS