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FLASH GENE

Symbol

EEA1

contributors: mct - updated : 14-06-2014

HGNC name	early endosome antigen 1
HGNC id	3185

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003566 12 - 8019 162.3 1411 - 1995 7768953

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal zinc finger motif
	a cysteine-rich C terminal FYVE zinc finger motif
	a coiled coil structure
	multiple N glycosylation,phosphorylation
	N-miristoylation sites

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic
text	colocalizing with TF, RB5 in early endosomes
	localized in the soma and in the postsynaptic nerve terminals (
	can colocalize with KIAA0319

basic FUNCTION	involved in neuronal synaptic vesicle function and axonal transport and growth, and may undergo calcium-dependent conformational changes that are required for binding to SNAP25
	interaction between EEA1 and Rabenosyn-5 (ZFYVE20), which facilitate endosome tethering, sorting, and fusion
	interacting with VCP (function of VCP in endocytic trafficking by establishing EEA1 as a new VCP substrate)
	peripheral membrane protein associated with the cytoplasmic face of early endosomes, controls vesicle fusion during endocytosis, as extensively studied in non-neuronal cells
	EEA1 and ZFYVE20 facilitate endosome tethering, sorting, and fusion
	serves a novel function as an obligate scaffold for AGTR2-induced AKT1 activation in early endosomes
	endocytosis allows cargo to enter a series of specialized endosomal compartments, beginning with early endosomes harboring RAB5 and its effector EEA1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RAB5 by the FYVE motif, regulating endosome fusion
	interaction between EEA1 and SNAP25 dependent on the leucine zipper and a newly identified methyl-accepting domain of EEA1
	interaction between EEA1 and Rabenosyn-5 (ZFYVE20), which facilitate endosome tethering, sorting, and fusion
	interacting with VCP (function of VCP in endocytic trafficking by establishing EEA1 as a new VCP substrate)
	PLEKHF2 is an interactor of the endosomal-tethering protein EEA1, and colocalized strongly with EEA1 in microdomains of the endosome membrane
	GNAS facilitates EEA1 endosome maturation, limits EGFR signaling from EEA1 endosomes, and inhibits cell proliferation

cell & other

REGULATION

Other	regulated by VCP (may regulate the size of early endosomes by governing the oligomeric state of EEA1)
	MAPK14 can phosphorylate the RAB5 effectors EEA1 and ZFYVE20 on Thr-1392 and Ser-215, respectively, and these phosphorylation events regulate the recruitment of EEA1 and ZFYVE20 to membranes

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS