SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| colocalizing with TF, RB5 in early endosomes |
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localized in the soma and in the postsynaptic nerve terminals ( |
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can colocalize with KIAA0319 |
basic FUNCTION
| involved in neuronal synaptic vesicle function and axonal transport and growth, and may undergo calcium-dependent conformational changes that are required for binding to SNAP25 |
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interaction between EEA1 and Rabenosyn-5 (ZFYVE20), which facilitate endosome tethering, sorting, and fusion |
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interacting with VCP (function of VCP in endocytic trafficking by establishing EEA1 as a new VCP substrate) |
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peripheral membrane protein associated with the cytoplasmic face of early endosomes, controls vesicle fusion during endocytosis, as extensively studied in non-neuronal cells |
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EEA1 and ZFYVE20 facilitate endosome tethering, sorting, and fusion |
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serves a novel function as an obligate scaffold for AGTR2-induced AKT1 activation in early endosomes |
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endocytosis allows cargo to enter a series of specialized endosomal compartments, beginning with early endosomes harboring RAB5 and its effector EEA1 |
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