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FLASH GENE
Symbol EEA1 contributors: mct - updated : 14-06-2014
HGNC name early endosome antigen 1
HGNC id 3185
Location 12q21.31      Physical location : 93.166.285 - 93.323.107
Synonym name
  • early endosome antigen 1, 162kD
  • zinc finger FYVE domain-containing protein 2
  • endosome-associated protein p162
  • Synonym symbol(s) ZFYVE2, MST105, MSTP105
    DNA
    TYPE functioning gene
    STRUCTURE 156.82 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 8019 162.3 1411 - 1995 7768953
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal zinc finger motif
  • a cysteine-rich C terminal FYVE zinc finger motif
  • a coiled coil structure
  • multiple N glycosylation,phosphorylation
  • N-miristoylation sites
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • colocalizing with TF, RB5 in early endosomes
  • localized in the soma and in the postsynaptic nerve terminals (
  • can colocalize with KIAA0319
  • basic FUNCTION
  • involved in neuronal synaptic vesicle function and axonal transport and growth, and may undergo calcium-dependent conformational changes that are required for binding to SNAP25
  • interaction between EEA1 and Rabenosyn-5 (ZFYVE20), which facilitate endosome tethering, sorting, and fusion
  • interacting with VCP (function of VCP in endocytic trafficking by establishing EEA1 as a new VCP substrate)
  • peripheral membrane protein associated with the cytoplasmic face of early endosomes, controls vesicle fusion during endocytosis, as extensively studied in non-neuronal cells
  • EEA1 and ZFYVE20 facilitate endosome tethering, sorting, and fusion
  • serves a novel function as an obligate scaffold for AGTR2-induced AKT1 activation in early endosomes
  • endocytosis allows cargo to enter a series of specialized endosomal compartments, beginning with early endosomes harboring RAB5 and its effector EEA1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB5 by the FYVE motif, regulating endosome fusion
  • interaction between EEA1 and SNAP25 dependent on the leucine zipper and a newly identified methyl-accepting domain of EEA1
  • interaction between EEA1 and Rabenosyn-5 (ZFYVE20), which facilitate endosome tethering, sorting, and fusion
  • interacting with VCP (function of VCP in endocytic trafficking by establishing EEA1 as a new VCP substrate)
  • PLEKHF2 is an interactor of the endosomal-tethering protein EEA1, and colocalized strongly with EEA1 in microdomains of the endosome membrane
  • GNAS facilitates EEA1 endosome maturation, limits EGFR signaling from EEA1 endosomes, and inhibits cell proliferation
  • cell & other
    REGULATION
    Other regulated by VCP (may regulate the size of early endosomes by governing the oligomeric state of EEA1)
    MAPK14 can phosphorylate the RAB5 effectors EEA1 and ZFYVE20 on Thr-1392 and Ser-215, respectively, and these phosphorylation events regulate the recruitment of EEA1 and ZFYVE20 to membranes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS