Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ROBO4 contributors: mct - updated : 29-05-2018
HGNC name roundabout homolog 4, magic roundabout (Drosophila)
HGNC id 17985
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3859 - 1007 - 2009 18948384
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text embryonic stem cells, fetal spleen, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Ig-like domains
  • two fibronectin-like domains proline-rich motifs
  • a transmembrane segment
  • N-terminal signal peptide
  • four putative N-glycosylation sites within the extracellular domain
  • a transmembrane region
  • a proline-rich region within its intracellular domain
  • and a cytoplasmic tail
    • HOMOLOGY
    intraspecies homolog to ROBO1
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • ROBO family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • ROBO4 partially colocalizes with FLT1 in endocytic vesicles, whereas SCARB1 shows more extensive colocalization with FLT1 on the surface of podocytes
    • basic FUNCTION
  • roundabout/SLIT interactions are likely to have a role in angiogenesis
  • axon guidance molecules that have recently been identified to play a role in vascular guidance
  • implicated in endothelial cell migration and angiogenesis
  • key role for Robo-Slit signaling in vertebrate longitudinal axon guidance and highlight the importance of context-specific guidance cues during navigation within complex pathways
  • having aa guardianship role in normal development, and can functions to restrain VEGF/KDR signaling during sprouting angiogenesis that generates alveolar blood supply
  • role for SLIT/ROBO signaling in maintaining vascular homeostasis during mammary morphogenesis
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS angiogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLIT by its extra cellular domain
  • interact with ROBO1 and share molecules such as SLIT2, ENAH and ARHGAP1 (specific components of the Robo signaling apparatus that work together to guide directional migration of endothelial cells)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS