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FLASH GENE
Symbol ROBO4 contributors: mct - updated : 29-05-2018
HGNC name roundabout homolog 4, magic roundabout (Drosophila)
HGNC id 17985
DNA
TYPE functioning gene
STRUCTURE 13.72 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • a 119 -GABP-binding site, having a role in mediating Robo4 expression in the intact endothelium
  • 3-kb upstream promoter contains information for cell type-specific expression in the intact endothelium
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3859 - 1007 - 2009 18948384
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text embryonic stem cells, fetal spleen, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Ig-like domains
  • two fibronectin-like domains proline-rich motifs
  • a transmembrane segment
  • N-terminal signal peptide
  • four putative N-glycosylation sites within the extracellular domain
  • a transmembrane region
  • a proline-rich region within its intracellular domain
  • and a cytoplasmic tail
  • HOMOLOGY
    intraspecies homolog to ROBO1
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • ROBO family
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • ROBO4 partially colocalizes with FLT1 in endocytic vesicles, whereas SCARB1 shows more extensive colocalization with FLT1 on the surface of podocytes
  • basic FUNCTION
  • roundabout/SLIT interactions are likely to have a role in angiogenesis
  • axon guidance molecules that have recently been identified to play a role in vascular guidance
  • implicated in endothelial cell migration and angiogenesis
  • key role for Robo-Slit signaling in vertebrate longitudinal axon guidance and highlight the importance of context-specific guidance cues during navigation within complex pathways
  • having aa guardianship role in normal development, and can functions to restrain VEGF/KDR signaling during sprouting angiogenesis that generates alveolar blood supply
  • role for SLIT/ROBO signaling in maintaining vascular homeostasis during mammary morphogenesis
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS angiogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLIT by its extra cellular domain
  • interact with ROBO1 and share molecules such as SLIT2, ENAH and ARHGAP1 (specific components of the Robo signaling apparatus that work together to guide directional migration of endothelial cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS