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FLASH GENE
Symbol SPRR3 contributors: shn - updated : 29-03-2011
HGNC name small proline-rich protein 3
HGNC id 11268
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 splicing 918 - 169 - -
3 splicing 1002 - 169 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
digestiveesophagus    
Digestivemouthtongue   
 pharynx    
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage precursor of cornified cell envelope
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a central segment built up from eight octapeptide repeats, *K*PEP*
HOMOLOGY
interspecies ortholog to Sprr3, Mus musculus
ortholog to Sprr3, Rattus norvegicus
ortholog to SPRR3, Pan troglodytes
Homologene
FAMILY SPRR family of cornified envelope precursor proteins
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
text cornifin
basic FUNCTION
  • cross-linked envelope protein of keratinocytes
  • keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
  • function as a flexible cross-bridging protein to provide tensile strength or rigidity to the cell envelope of the stratified squamous epithelia
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text squamous cell differentiation
    PATHWAY
    metabolism
    signaling
    a component clustered in the epidermal differentiation complex (EDC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by the extracellular calcium (during esophageal epithelial cell differentiation)
    during squamous metaplasia induced by cigarette smoke exposure
    Other regulated by prolonged cyclic stress in vascular smooth muscle cells, which may have important implications to vascular disease
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary esophageal squamous cell carcinoma and in areas of cellular dysplasia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS