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FLASH GENE
Symbol SPRR3 contributors: shn - updated : 29-03-2011
HGNC name small proline-rich protein 3
HGNC id 11268
Location 1q21.3      Physical location : 152.974.222 - 152.976.331
Synonym name
  • 22 kDa pancornulin
  • cornifin beta
  • esophagin
  • Synonym symbol(s) SPRC, SPR3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text
  • clustered in the epidermal differentiation complex (EDC)
  • intragenic duplications that create a characteristic proline-rich repeats in the coding sequence, an alternative noncoding exon, and a 200-bp polypyrimidine tract in the promoter region
  • STRUCTURE 2.11 kb     2 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • open reading frame in a single exon
  • OCT1, OCT3 and two CEBPB binding sites
  • MAPPING cloned Y linked   status confirmed
    Map cen - D1S2345 - D1S2343 - SPRR3 - D1S2346 - D1S2715 - tel
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 918 - 169 - -
    3 splicing 1002 - 169 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    digestiveesophagus    
    Digestivemouthtongue   
     pharynx    
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage precursor of cornified cell envelope
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a central segment built up from eight octapeptide repeats, *K*PEP*
    HOMOLOGY
    interspecies ortholog to Sprr3, Mus musculus
    ortholog to Sprr3, Rattus norvegicus
    ortholog to SPRR3, Pan troglodytes
    Homologene
    FAMILY SPRR family of cornified envelope precursor proteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text cornifin
    basic FUNCTION
  • cross-linked envelope protein of keratinocytes
  • keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
  • function as a flexible cross-bridging protein to provide tensile strength or rigidity to the cell envelope of the stratified squamous epithelia
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text squamous cell differentiation
    PATHWAY
    metabolism
    signaling
    a component clustered in the epidermal differentiation complex (EDC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by the extracellular calcium (during esophageal epithelial cell differentiation)
    during squamous metaplasia induced by cigarette smoke exposure
    Other regulated by prolonged cyclic stress in vascular smooth muscle cells, which may have important implications to vascular disease
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary esophageal squamous cell carcinoma and in areas of cellular dysplasia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS