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FLASH GENE
Symbol MYO1A contributors: mct - updated : 28-08-2013
HGNC name myosin IA
HGNC id 7595
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 3658 - 1043 - 2005 15758024
28 - 3621 - 1043 - 2005 15758024
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestinejejunum  
 intestinelarge intestinecolon  
 stomach    
Hearing/Equilibriumearinnercochlea  
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensorystato-auditory  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal motor domain with ATP and actin-binding sites
  • a neck with three IQ calmodulin or calmodulin-like light chain binding domains
  • a tail containing a coiled coil segment
  • a myosin head-like domain
  • a C terminal globular domain, C-terminal tail homology 1 (TH1) domain, mediating the ability to bind to microvillar membrane
  • HOMOLOGY
    interspecies homolog to bovine Myo1a
    Homologene
    FAMILY myosin family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text brush border
    basic FUNCTION
  • unconventional, apparently non filamentous, involved in directing the movement of organelles along actin filaments
  • critical multifunctional component of the enterocyte, required for maintaining the normal composition and highly ordered structure of the brush border
  • regulates the polarization/differentiation of colorectal cancer cells, is frequently mutated/methylated in colorectal tumors, and has tumor-suppressor activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • important regulator of CFTR traffic and anion transport in the BBM (brush border membrane) of villus enterocytes, suggesting that MYO1A may power apical CFTR movement into the BBM from subapical endosomes
  • cell & other
  • targeting to microvilli using multiple membrane binding motifs in the tail homology 1 (TH1) domain
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA48
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    frequently inactivated in colorectal tumors by genetic and epigenetic mechanism
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MYO1A levels can be used to predict the probability of patient survival in colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Myo1a demonstrate no overt physiological symptoms, suggesting that other myosins may compensate for the loss of Myo1a in these animals