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FLASH GENE
Symbol PDE1B contributors: mct/npt - updated : 30-06-2008
HGNC name phosphodiesterase 1B, calmodulin-dependent
HGNC id 8775
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, head to head
STRUCTURE 29.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D12S325 - D12S1707 - PDE1B - ITGA5 - ITGA7 ITGA7 - CDK2 - ERBB3 - GLI - D12S1691 - qter
Authors Gene Map
Physical map
HOXC5 12q13.3 homeo box C5 LOC387863 12 LOC387863 SMUG1 12q13.11-q13.3 single-strand selective monofunctional uracil DNA glycosylase CBX5 12q12 chromobox homolog 5 (HP1 alpha homolog, Drosophila) HNRPA1 12q13.1 heterogeneous nuclear ribonucleoprotein A1 NFE2 12q13.1-q13.2 nuclear factor (erythroid-derived 2), 45kDa COPZ1 12q13.2-q13.3 coatomer protein complex, subunit zeta 1 GPR84 12q13.13 G protein-coupled receptor 84 ZNF385 12q13.13 zinc finger protein 385 ITGA5 12q11-q13 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) LOC387864 12 LOC387864 FLJ32942 12q13.13 hypothetical protein FLJ32942 HEM1 12q13.1 hematopoietic protein 1 PDE1B 12q13 phosphodiesterase 1B, calmodulin-dependent PPP1R1A 12q13.13 protein phosphatase 1, regulatory (inhibitor) subunit 1A LACRT 12q13 lacritin DCD 12q13.1 dermcidin VDAC5P 12 voltage-dependent anion channel 5, pseudogene LOC118430 12q small breast epithelial mucin KIAA0748 12q13.13 small breast epithelial mucin NEUROD4 12q13.13 neurogenic differentiation 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 3236 61.4 536 - Bender (2006)
- - 2985 - 516 - Bender (2005), Fidock (2002)
  • selectively increased by GM-CSF by stimulation of transcription at a previously unknown transcriptional start site
  • has a different N-terminal sequence because of a separate first exon that is located 11.5 kb downstream from the PDE1B1 first exon
  • diverges from PDE1B1 by the replacement of the first 38 residues by an alternative 18, which is predicted to be functionally significant
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunespleen    
    Nervousbrainhindbraincerebellum  
     braindiencephalonhypothalamus  
     brainbasal nucleicaudate nucleus  
     brain   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines leukemic cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulates cGMP and plays a lesser role in cAMP regulation in response to cyclase agonists
  • plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels
  • may have a regulatory role in multiple immune cell types
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS