Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

FMNL1

contributors: mct - updated : 28-02-2014

HGNC name	formin-like
HGNC id	1212

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	25.41 kb     27 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map

see DDPAC

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005892 27 - 3973 NP_005883 - 1100 - 2003 12684686 variant 2 - - - isoform 2 - 1114 - 2003 12684686 FMNL1gamma - - - - - specifically located at the cell membrane and cortex in diverse cell lines 2009 19815554 with an intron retention at the C terminus affecting the diaphanous autoinhibitory domain (DAD)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic mature hematopoietic Homo sapiens Lymphoid/Immune macrophage Homo sapiens Lymphoid/Immune natural killer

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

FH1-FH2 domains lacking activity to stimulate potent filopodia assembly, despite possessing similar biochemical activities and being highly homologous to FMNL3

HOMOLOGY

interspecies	homolog to Drosophila diaphanous protein
	homolog to murine Fmnl

Homologene

FAMILY

formin family of actin nucleators

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	localizes to the actin-rich cores of primary macrophage podosomes (pMID: 20617518)

basic FUNCTION	playing a role in the control of reorganization of the actin cytoskeleton in association with RAC and in the regulation of the signal for cell survival
	DIAPH2 and FMNL1 mediate the formation of highly elastic F-actin networks as effectively and rapidly as alpha-actinin and filamin
	is potentially responsible for modifying actin at the macrophage podosome and may be involved in actin cytoskeleton dynamics during adhesion and migration within tissues
	regulates cellular F-actin levels required to maintain structural integrity of the Golgi complex and lysosomes
	DIAPH1 and FMNL1 have been implicated in centrosome reorientation to the immunological synapse of T lymphocytes
	DIAPH1 and FMNL1 are novel regulators of spirochete uptake by human immune cells
	stimulates leukemia cell proliferation as well as migration, and potentially contributes to leukemogenesis and could act in part through RAC1 regulation
	upon TCR triggering the INF2 formin, together with the formins DIAPH1 and FMNL1, promotes the formation of a specialized array of stable detyrosinated MT that breaks the symmetrical organization of the T-cell microtubule (MT) cytoskeleton
	DIAPH2, DAAM1, FMNL1, and FMNL2 were found to be required for myofibrillogenesis, non-redundantly

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	associating with AKT1
	after RAC1-dependent activation of FMNL1, SRGAP2 mediates a potent mechanism to limit the duration of RAC1 action and inhibit formin activity during rapid actin dynamics

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in lymphoid malignancies, chronic lymphocytic leukemia tumoral     --over   in Burkitt lymphoma, pancreatic cancer, prostate cancer, and lung large cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS