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FLASH GENE
Symbol NUP58 contributors: mct - updated : 25-01-2017
HGNC name nucleoporin 58
HGNC id 20261
DNA
TYPE functioning gene
STRUCTURE 48.64 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4335 60.8 599 - 2011 22036567
15 - 4299 59.6 587 - 2011 22036567
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
  • NUPL1 family
    • CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • putative nucleoporin
  • NUP58 contributes to bipolar spindle formation, whereas AVL9 and DENND5A participate in both intracellular trafficking and cell cycle progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleocyte plasmic bilateral transport of macro molecules
    PATHWAY
    metabolism
    signaling
    a component
  • NUP62 complex contains the FG-repeat proteins NUP62, NUP54, and NUP58 and is located in the center of the nuclear pore complex
  • nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, NUP54, NUP58, and NUP62
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP58 is anchored to the triple complex primarily via its interaction with a cognate segment of NUP54
  • allosteric coupling between a structured domain of a channel nucleoporin (NUP58) and its neighboring disordered domain in interaction with another channel nucleoporin (NUP54) and a transport factor (KPNB1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS