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FLASH GENE
Symbol NUP58 contributors: mct - updated : 25-01-2017
HGNC name nucleoporin 58
HGNC id 20261
Location 13q12.13      Physical location : -
Synonym name
  • KIAA0410 gene product
  • nucleoporin p58/p45
  • nucleoporin like 1
    • Synonym symbol(s) KIAA0410, PRO2463, NUPL1, NUP45
    DNA
    TYPE functioning gene
    STRUCTURE 48.64 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4335 60.8 599 - 2011 22036567
    15 - 4299 59.6 587 - 2011 22036567
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • NUPL1 family
    • CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • putative nucleoporin
  • NUP58 contributes to bipolar spindle formation, whereas AVL9 and DENND5A participate in both intracellular trafficking and cell cycle progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleocyte plasmic bilateral transport of macro molecules
    PATHWAY
    metabolism
    signaling
    a component
  • NUP62 complex contains the FG-repeat proteins NUP62, NUP54, and NUP58 and is located in the center of the nuclear pore complex
  • nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, NUP54, NUP58, and NUP62
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP58 is anchored to the triple complex primarily via its interaction with a cognate segment of NUP54
  • allosteric coupling between a structured domain of a channel nucleoporin (NUP58) and its neighboring disordered domain in interaction with another channel nucleoporin (NUP54) and a transport factor (KPNB1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS