| basic FUNCTION
| calmodulin dependent serine/threonine phosphatase 2B, catalytic subunit |
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involved in osteoclast regulation |
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playing a role in the calmodulin activation of calcineurin |
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regulating bone formation through an effect on osteoblast differentiation |
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may regulate the kinase activity of CDK4 in a cell cycle-dependent manner and may be an important component of the negative regulation of CDK4 |
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participates in regulation of AQP2 expression, phosphorylation, and function |
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its activation is required for lytic granule exocytosis but it is not the sole Ca2+-dependent step |
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only Ca(2+)-dependent serine/threonine-specific protein phosphatase and is considered a potential regulator of many intracellular signaling events  |
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is required for expression of inflammatory factors, and reveal a novel process of calcineurin-mediated activation of NFKB1 |
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activation promotes apoptosis of glomerular podocytes |
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CAMK2D and PPP3CA provide likely a switch-like mechanism that controls Ca-dependent LIMK1, SSH1 and CFL1 activation, and subsequently actin cytoskeletal reorganization |
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is an important regulator of SLC6A4 activity in the adult brain |
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is a calmodulin-activated, serine/threonine phosphatase that is necessary for cardiac, vasculature, and nervous system development, as well as learning and memory, skeletal muscle growth, and immune system activation |
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affect a series of signalling pathways and exert a proapoptotic effect in cardiomyocytes |
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novel role of calcineurin in suppressing adaptive autophagy during oxidative stress by downregulating the AMPK signalling pathway |
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likely a negative feedback of cooperative action of CALM1, GAP43, and PPP3CA on P/Q and L-type channels activity |
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involved in synaptic vesicle recycling, in epilepsy and neurodevelopmental disorders, further strengthening the role of synaptic vesicle cycle dysregulation in epilepsy |
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in the brain plays an important role in synaptic transmission via regulation of the signaling response to calcium ions |
