basic FUNCTION
| xanthine oxidase (dehydrogenase), catalyzing the oxidation of hypoxanthine to purine and purine to uric acid |
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plays a physiological role in milk (e.g. in secretion) equal in importance to its catalytic function as an enzyme |
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synergistic action with ALOXE3, group of oxidized fatty acids which can function as PPAR{gamma} activators |
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required for functional differentiation of mammary epithelial cells |
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XDH activity and/or its expression level to contribute to macrophage foam cell formation |
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activity creates both oxidant and anti-oxidant products that are implicated in the development of hypertension, smoking vascular injury, dyslipidemia and diabetes, which are the main risk factors of atherosclerosis |
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is abundant in wounds and participates in normal wound healing through effects on ROS production |
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catalyzes the formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of purine metabolism starting from ribose-5-phosphate |
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XDH activity may be potentially involved in adiposity and subclinical inflammation in humans |