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FLASH GENE
Symbol SFR1 contributors: mct - updated : 28-09-2011
HGNC name SWI5-dependent recombination repair 1
HGNC id 29574
DNA
TYPE functioning gene
STRUCTURE 4.33 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1447 - 245 - 1999 10409428
4 - 1518 - 232 - 1999 10409428
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainmedulla oblongata  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a middle coiled-coil region
    • HOMOLOGY
    interspecies homolog to s. Pombe Mei5
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text colocalized with DMC1 and RAD51 on meiotic chromosome
    basic FUNCTION
  • involved in recombination and DNA repair
  • SWI5-SFR1 overcomes, at least partly, the inhibitory effect of RPA, representing a novel class of mediator (
  • SWI5-SFR1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks
  • SWI5-SFR1 has an evolutionarily conserved function in homologous recombination repair
  • SWI5-SFR1 may potentially play important roles both in mitotic and meiotic homologous recombination reactions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with DMC1 and RAD51 for a role in interhomolog recombination during meiosis
  • SWI5-SFR1 complex plays an important role in homologous recombination
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SWI5 (C-terminal SWI5 domain of SWI5 and the middle coiled-coil region of SFR1 dictate this conserved interaction)
  • SWI5-SFR1 directly interacts with RAD51 and plays a critical role in homologous recombination repair
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS