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FLASH GENE
Symbol SFR1 contributors: mct - updated : 28-09-2011
HGNC name SWI5-dependent recombination repair 1
HGNC id 29574
Location 10q25.1      Physical location : -
Synonym name
  • meiosis specific protein 5
  • MEI5 recombination repair protein homolog
  • chromosome 10 open reading frame 78
    • Synonym symbol(s) bA373N18.1, MEI5, c10orf78, RP11-373N18.1, FLJ41960, MEIR5
    DNA
    TYPE functioning gene
    STRUCTURE 4.33 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1447 - 245 - 1999 10409428
    4 - 1518 - 232 - 1999 10409428
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a middle coiled-coil region
    • HOMOLOGY
    interspecies homolog to s. Pombe Mei5
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text colocalized with DMC1 and RAD51 on meiotic chromosome
    basic FUNCTION
  • involved in recombination and DNA repair
  • SWI5-SFR1 overcomes, at least partly, the inhibitory effect of RPA, representing a novel class of mediator (
  • SWI5-SFR1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks
  • SWI5-SFR1 has an evolutionarily conserved function in homologous recombination repair
  • SWI5-SFR1 may potentially play important roles both in mitotic and meiotic homologous recombination reactions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with DMC1 and RAD51 for a role in interhomolog recombination during meiosis
  • SWI5-SFR1 complex plays an important role in homologous recombination
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SWI5 (C-terminal SWI5 domain of SWI5 and the middle coiled-coil region of SFR1 dictate this conserved interaction)
  • SWI5-SFR1 directly interacts with RAD51 and plays a critical role in homologous recombination repair
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS