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FLASH GENE
Symbol CATSPER3 contributors: - updated : 21-09-2007
HGNC name cation channel, sperm associated 3
HGNC id 20819
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text in head-to-tail orientation with DCOHM gene
STRUCTURE 43.00 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinelarge intestinecolon  
 pharynx   highly
Reproductivemale systemtestis  predominantly
 male systemprostate  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatozoa
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil protein-protein interaction domains in the C-terminal tail
  • a single-ion transport domain with six transmembrane spanning regions, in which the fourth transmembrane region resembles a voltage sensor and a pore-forming region lies between transmembrane regions 5 and 6
    • mono polymer heteromer , tetramer
    HOMOLOGY
    intraspecies homolog to CATSPER1, CATSPER2
    Homologene
    FAMILY Catsper family
    CATEGORY receptor membrane ligand ion channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • voltage-gated Ca2+ channel
  • forms a functional heterotetrameric channel in sperm (in association with Casper 1, 2 and 3)
  • cation-channel protein having roles in acrosome reaction and male fertility
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    Ca2+ binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS