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FLASH GENE
Symbol MOAP1 contributors: mct - updated : 05-09-2018
HGNC name modulator of apoptosis 1
HGNC id 16658
DNA
TYPE functioning gene
STRUCTURE 2.71 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2435 - 351 - 2009 19100260
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas    
Nervousbrainhindbraincerebellum  
 brain   highly
Skin/Tegumentskin    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines retinoblastoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BH3-like motif
  • C-terminal region associated with the death domain of TNFRSF1A
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY PNMA family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • mitochondria-enriched protein
  • MOAP1 is a BAX-binding protein enriched at the outer mitochondrial membrane (OMM)
  • basic FUNCTION
  • mediates caspase-dependent apoptosis
  • is a direct mitochondrial target of BAX
  • apoptotic stimuli can facilitate the proapoptotic function of BAX in mitochondria through stabilization of MOAP1
  • association of RASSF1 and MOAP1 with death receptors involves an ordered recruitment to receptor complexes to promote cell death and inhibit tumor formation
  • is a BH3-like protein that plays key roles in cell death or apoptosis
  • role for MOAP1 in FAS signaling in the liver by promoting MTCH2-mediated BID recruitment to mitochondria
  • pro-apoptotic tumor suppressor molecule with a growing set of known interacting partners
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with BCL2 and BCL-XL
  • BAX-associating protein (MOAP1 may act as an effector for promoting BAX function in mitochondria)
  • binding TNFRSF1A (association domains on both MOAP1 and RASSF1 were essential for death receptor-dependent apoptosis)
  • TRIM39-binding protein (extends the half-life of MOAP1 by inhibiting its poly-ubiquitination process)
  • MOAP1 is a novel substrate of the anaphase-promoting complex (APC/C(Cdh1)) ubiquitin ligase
  • influence of TRIM39 on MOAP1 levels stems from the ability of TRIM39 (a RING domain E3 ligase) to directly inhibit APC/C(Cdh1)-mediated protein ubiquitylation
  • is an integral partner to the tumor suppressor protein, (RASSF1), and functions to activate the BCL2 family pro-apoptotic protein BAX
  • PNMA2 functions as antagonist of MOAP1 and PNMA1 through heterodimeric interaction
  • BAX-binding protein enriched at the outer mitochondrial membrane (OMM)
  • PNMA5 interacts with MOAP1 and N-terminal domain of PNMA5 is required for interaction with MOAP1
  • robust association with RACK1, a versatile scaffolding protein that responds to activation of protein kinase C
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    sensitizes cells to apoptotic stimuli and promotes recombinant BAX-mediated cytochrome c release from isolated mitochondria
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Moap-1-deficient mice are resistant to Fas-induced hepatocellular apoptosis and lethality