Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NUP54 contributors: mct - updated : 25-01-2017
HGNC name nucleoporin 54kDa
HGNC id 17359
DNA
TYPE functioning gene
STRUCTURE 33.86 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2237 - 459 - 2014 24574455
12 - 2381 - 507 - 2014 24574455
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure
  • forms a tetrameric, helical bundle that is structurally "conditioned" for instability by a central patch of polar hydrogen-bonded residues
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • exhibits large conformational plasticity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, NUP54, NUP58, and NUP62
  • NUP62 complex contains the FG-repeat proteins NUP62, NUP54, and NUP58 and is located in the center of the nuclear pore complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP58 is anchored to the triple complex primarily via its interaction with a cognate segment of NUP54
  • allosteric coupling between a structured domain of a channel nucleoporin (NUP58) and its neighboring disordered domain in interaction with another channel nucleoporin (NUP54) and a transport factor (KPNB1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS