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FLASH GENE
Symbol NUP54 contributors: mct - updated : 25-01-2017
HGNC name nucleoporin 54kDa
HGNC id 17359
Location 4q21.1      Physical location : 77.035.817 - 77.069.655
DNA
TYPE functioning gene
STRUCTURE 33.86 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2237 - 459 - 2014 24574455
12 - 2381 - 507 - 2014 24574455
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure
  • forms a tetrameric, helical bundle that is structurally "conditioned" for instability by a central patch of polar hydrogen-bonded residues
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • exhibits large conformational plasticity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, NUP54, NUP58, and NUP62
  • NUP62 complex contains the FG-repeat proteins NUP62, NUP54, and NUP58 and is located in the center of the nuclear pore complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP58 is anchored to the triple complex primarily via its interaction with a cognate segment of NUP54
  • allosteric coupling between a structured domain of a channel nucleoporin (NUP58) and its neighboring disordered domain in interaction with another channel nucleoporin (NUP54) and a transport factor (KPNB1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS