| basic FUNCTION
| mediating the voltage-dependent potassium ion permeability of excitable membranes |
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assuming opened or closed conformations in response to the voltage difference across the membrane |
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involved in the pathway regulating body weight and energy homeostasis and in the pathway regulating glucose homeostasis (regulation of insulin sensitivity) |
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regulating membrane potential and calcium signaling in T cells |
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having a molecular role in apoptosis |
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required for induction of apoptosis by BAX, at least in lymphocytes |
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slower activation kinetics of KCNA3 in immunological synapse is likely to be the consequence of the redistribution of the channels into distinct membrane domains  |
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might play a role in the apoptotic signalling not only in lymphocytes but also in other cells |
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forms the Kv channel of the platelet and megakaryocyte, which sets the resting membrane potential, regulates agonist-evoked Ca(2+) increases and influences circulating platelet numbers |
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may regulate neurotransmitter release differentially in neurons that respond to different frequencies of sound |
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KCNA3 potassium channels are functional in vascular smooth muscle cells and have positive effects on cell migration |
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regulates the duration of the action potential in the presynaptic terminal of C fibers, limiting transmitter release to the postsynaptic cell |
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plays an important role in regulating membrane excitability in diverse cell types ranging from T-lymphocytes to neurons |
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KCNA3 channels play an important role in T-cell activation, and their inhibition suppresses T-cell function |
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signaling cascade linking its functional expression to cell proliferation is activated by the voltage-dependent conformational change of the channels without needing ion conduction |
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heavily glycosylated membrane protein, playing an essential role in modulating membrane excitability in many cell types |
