Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AMPD3 contributors: - updated : 05-01-2006
HGNC name adenosine monophosphate deaminase (isoform E)
HGNC id 470
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence alternative promoter
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing - - 216 erythrocytes Mahnke,Zizelman
- splicing 2212 - 658 erythrocytes Mahnke,Zizelman
- splicing 3915 88.8 767 thymus,brain,heart,prostate,kidney,lung,skeletal muscle,erythrocytes Mahnke,Zizelman
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies ortholog to murine Ampd3
homolog to Drosophila CG11058
homolog to C.elegans C34F11.3
Homologene
FAMILY adenosine and AMP deaminase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • catalyzing the D amination of adenosin monophosphate into inosin monophosphate
  • AMP deaminase plays a critical role in energy metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other cytoplasmic membrane and phosphatidylinositol 4,5-bisphosphate
    REGULATION
    inhibited by phosphatidylinositol 4,5-bisphosphate
    pH and association with plasmic membrane
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS