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FLASH GENE

Symbol

AMOTL1

contributors: mct/pgu - updated : 23-05-2017

HGNC name	angiomotin like 1
HGNC id	17811

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	108.00 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed AMOTL1-V1 - - - 98.4 882 - 2002 11733531 AMOTL1-V2 - - 5299 106.6 956 - 2002 11733531

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel capillary     highly Homo sapiens Digestive salivary gland sublingual         salivary gland submandibular         salivary gland parotid       Endocrine pancreas         Lymphoid/Immune thymus       highly Urinary bladder       highly Visual eye lacrimal gland

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a polyglutamic acid repeat at the N-terminal region
	a coiled-coil domain
	a consensus motif for binding to PDZ domain at the C terrminus, C-terminal PDZ-binding motifs, required for the interactions with AMOT, AMOTL2, MPDZ, and INADL

HOMOLOGY

interspecies	homolog to murine Amotl1
	homolog to C.elegans C15B12.1

intraspecies

homolog to Leman coiled-coil protein

Homologene

FAMILY

motins family, Amot/JEAP family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	plasma membrane,junction,tight
text	peripheral membrane protein
	apparent at TJs as well as apical membranes, and mostly co-localized with MPDZ

basic FUNCTION	involved in the control of paracellular permeability and maintain cell polarity
	mediates the inhibitory effect of angiostatin on endothelial cell migration and tube formation
	not only co-localizes with filamentous actin but also significantly modifies the architecture of the actin cytoskeleton
	involved in actin-cytoskeleton-based processes, in part, via its interaction with a p80-angiomotin-containing complex and the actin cytoskeleton
	AMOT appears to control the polarity of vascular tip cells whereas AMOTL1 mainly affects the stability of cell-cell junctions of the stalk cells
	AMOTL1 and AMOTL2 can regulate YAP1 cytoplasm-to-nucleus translocation through direct protein-protein interaction, which can occur independent of YAP1 phosphorylation status
	AMOT, AMOTL1 and AMOTL2, play critical roles in the Hippo pathway by regulating the subcellular localization of the co-activators YAP1 and TAZ

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

strucutural component of tight junction

INTERACTION

DNA

RNA

small molecule

protein	interacing with MPDZ and INADL (interaction not necessarily responsible for their proper subcellular distribution
	AMOTL1 and AMOTL2, are YAP1-associated proteins
	AMOT and AMOTL1 interact with YAP1 via the first WW domain of YAP1
	inhibits pro-apoptotic function of YAP1, whereas TJP2 enhances it
	AMOTL1 is an essential effector of the CDH2 mediated endothelial/pericyte junctional complex
	nuclear translocation of AMOTL1 islikely accompanied by YAP1 to promote cardiomyocyte proliferation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS