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FLASH GENE
Symbol AMOTL1 contributors: mct/pgu - updated : 23-05-2017
HGNC name angiomotin like 1
HGNC id 17811
Location 11q14.3      Physical location : 94.501.507 - 94.609.917
Synonym name junction-enriched and associated protein
Synonym symbol(s) JEAP
DNA
TYPE functioning gene
STRUCTURE 108.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 98.4 882 - 2002 11733531
- - 5299 106.6 956 - 2002 11733531
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselcapillary  highly Homo sapiens
Digestivesalivary glandsublingual   
 salivary glandsubmandibular   
 salivary glandparotid   
Endocrinepancreas    
Lymphoid/Immunethymus   highly
Urinarybladder   highly
Visualeyelacrimal gland   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a polyglutamic acid repeat at the N-terminal region
  • a coiled-coil domain
  • a consensus motif for binding to PDZ domain at the C terrminus, C-terminal PDZ-binding motifs, required for the interactions with AMOT, AMOTL2, MPDZ, and INADL
  • HOMOLOGY
    interspecies homolog to murine Amotl1
    homolog to C.elegans C15B12.1
    intraspecies homolog to Leman coiled-coil protein
    Homologene
    FAMILY motins family, Amot/JEAP family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • peripheral membrane protein
  • apparent at TJs as well as apical membranes, and mostly co-localized with MPDZ
  • basic FUNCTION
  • involved in the control of paracellular permeability and maintain cell polarity
  • mediates the inhibitory effect of angiostatin on endothelial cell migration and tube formation
  • not only co-localizes with filamentous actin but also significantly modifies the architecture of the actin cytoskeleton
  • involved in actin-cytoskeleton-based processes, in part, via its interaction with a p80-angiomotin-containing complex and the actin cytoskeleton
  • AMOT appears to control the polarity of vascular tip cells whereas AMOTL1 mainly affects the stability of cell-cell junctions of the stalk cells
  • AMOTL1 and AMOTL2 can regulate YAP1 cytoplasm-to-nucleus translocation through direct protein-protein interaction, which can occur independent of YAP1 phosphorylation status
  • AMOT, AMOTL1 and AMOTL2, play critical roles in the Hippo pathway by regulating the subcellular localization of the co-activators YAP1 and TAZ
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component strucutural component of tight junction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacing with MPDZ and INADL (interaction not necessarily responsible for their proper subcellular distribution
  • AMOTL1 and AMOTL2, are YAP1-associated proteins
  • AMOT and AMOTL1 interact with YAP1 via the first WW domain of YAP1
  • inhibits pro-apoptotic function of YAP1, whereas TJP2 enhances it
  • AMOTL1 is an essential effector of the CDH2 mediated endothelial/pericyte junctional complex
  • nuclear translocation of AMOTL1 islikely accompanied by YAP1 to promote cardiomyocyte proliferation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS