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FLASH GENE

Symbol

DCTN3

contributors: npt/mct - updated : 05-12-2008

HGNC name	dynactin 3 (p22)
HGNC id	2713

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	12 alternative transcripts altogether encoding 12 proteins (ACE/NCBI)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DCTN3-V1 7 - 846 2.09 186 - Karki, Humphray (2004) DCTN3-V2 7 - 947 1.98 176 - Karki, Humphray (2004)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive salivary gland       highly Endocrine thyroid       highly Lymphoid/Immune tonsils       highly Nervous brain         Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

very small coiled-coil domain

secondary structure

alpha-helical protein with very little coiled coil

HOMOLOGY

Homologene

FAMILY

dynactin subunit 3 family

CATEGORY

motor/contractile , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus,chromatin/chromosome,kinetochore
text	punctate cytoplasmic structures and centrosomes during interphase, mitotic spindle through mitosis, cleavage furrow and midbodies of dividing cells

basic FUNCTION

required for cytoplasmic movement of vesicles and organelles along microtubules

CELLULAR PROCESS	cell cycle, division, mitosis
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cytokinesis

PATHWAY

metabolism

signaling

a component

component of the large macromolecular complex, dynactin, required for the cytoplasmic dynein-driven movement of organelles along microtubules

INTERACTION

DNA

RNA

small molecule

protein	dynein DCTN1
	binding directly DCTN1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS