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FLASH GENE
Symbol DCTN3 contributors: npt/mct - updated : 05-12-2008
HGNC name dynactin 3 (p22)
HGNC id 2713
Location 9p13      Physical location : 34.613.547 - 34.620.496
Synonym name
  • dynactin light chain
  • dynactin complex subunit 22 kDa subunit
    • Synonym symbol(s) DCTN-22, MGC111190 , DCTN22, p22
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text 12 alternative transcripts altogether encoding 12 proteins (ACE/NCBI)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 846 2.09 186 - Karki, Humphray (2004)
    7 - 947 1.98 176 - Karki, Humphray (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrinethyroid   highly
    Lymphoid/Immunetonsils   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • very small coiled-coil domain
    • secondary structure alpha-helical protein with very little coiled coil
    HOMOLOGY
    Homologene
    FAMILY
  • dynactin subunit 3 family
    • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text punctate cytoplasmic structures and centrosomes during interphase, mitotic spindle through mitosis, cleavage furrow and midbodies of dividing cells
    basic FUNCTION
  • required for cytoplasmic movement of vesicles and organelles along microtubules
    • CELLULAR PROCESS cell cycle, division, mitosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cytokinesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the large macromolecular complex, dynactin, required for the cytoplasmic dynein-driven movement of organelles along microtubules
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dynein DCTN1
  • binding directly DCTN1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS