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FLASH GENE
Symbol MS4A3 contributors: - updated : 18-03-2006
HGNC name membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
HGNC id 7317
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 14.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
cell lineage myelomonocytes
cell lines erythroleukemia cells
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short intracellular domain
  • four transmembrane segments (4TM) and a long cytoplasmic tail
  • HOMOLOGY
    Homologene
    FAMILY membrane-spanning 4-domains, subfamily A
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transmembrane (TM) protein involved in intracellular signaling
  • acting as a hematopoietic modulator for the G(1)-S cell cycle transition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component component of oligomeric cell surface complex involved in signal transduction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS