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FLASH GENE
Symbol MS4A3 contributors: - updated : 18-03-2006
HGNC name membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
HGNC id 7317
Location 11q12      Physical location : 59.824.100 - 59.838.587
Genatlas name CD20 antigen-like
Synonym name
  • CD20 antigen homolog
  • IgE receptor beta chain
  • IgE receptor beta subunit
    • Synonym symbol(s) HTM4, CD20L
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 14.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    cell lineage myelomonocytes
    cell lines erythroleukemia cells
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short intracellular domain
  • four transmembrane segments (4TM) and a long cytoplasmic tail
    • HOMOLOGY
    Homologene
    FAMILY membrane-spanning 4-domains, subfamily A
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transmembrane (TM) protein involved in intracellular signaling
  • acting as a hematopoietic modulator for the G(1)-S cell cycle transition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component component of oligomeric cell surface complex involved in signal transduction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS