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FLASH GENE
Symbol AGPAT3 contributors: mct - updated : 29-10-2010
HGNC name 1-acylglycerol-3-phosphate O-acyltransferase 3
HGNC id 326
DNA
TYPE functioning gene
STRUCTURE 122.36 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 6435 43 376 - 2006 16620771
also called gamma 1
10 splicing 6555 - 376 - 2006 16620771
also called gamma 2
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunetonsils   highly
Urinarykidney   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytoplasmic N-terminus with AAs 1 to 125, which contains motif I (residues 95–101)
  • four conserved motifs (I–IV), whose invariant residues appear to be important for catalysis and/or substrate recognition
  • two transmembrane domains, one of which separates motifs I and II, which are thought to form a functional unit that is critical for enzymatic activity
  • starting around residues 331–339 and extending to residue 376 is a cytoplasmic C-terminal tail
  • HOMOLOGY
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text localized to the endoplasmic reticulum (ER) and Golgi complex
    basic FUNCTION
  • converting lysophosphatidic into phosphatidic acid
  • direct role in regulating membrane trafficking and organelle structure
  • involved in the structure and function of the Golgi complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    second step in de novo phospholipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS