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FLASH GENE
Symbol AGPAT3 contributors: mct - updated : 29-10-2010
HGNC name 1-acylglycerol-3-phosphate O-acyltransferase 3
HGNC id 326
Location 21q22.3      Physical location : 45.285.115 - 45.407.474
Synonym name
  • lysophosphatidic acid acyltransferase-gamma1
  • 1-AGP acyltransferase 3
  • gene similar to plant lysophosphatidic acid acyltransferase9
    • Synonym symbol(s) LPAAT-GAMMA1, LPAAT-gamma, MGC4604
    EC.number 2.3.1.51
    DNA
    TYPE functioning gene
    STRUCTURE 122.36 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 6435 43 376 - 2006 16620771
    also called gamma 1
    10 splicing 6555 - 376 - 2006 16620771
    also called gamma 2
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Urinarykidney   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cytoplasmic N-terminus with AAs 1 to 125, which contains motif I (residues 95–101)
  • four conserved motifs (I–IV), whose invariant residues appear to be important for catalysis and/or substrate recognition
  • two transmembrane domains, one of which separates motifs I and II, which are thought to form a functional unit that is critical for enzymatic activity
  • starting around residues 331–339 and extending to residue 376 is a cytoplasmic C-terminal tail
    • HOMOLOGY
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text localized to the endoplasmic reticulum (ER) and Golgi complex
    basic FUNCTION
  • converting lysophosphatidic into phosphatidic acid
  • direct role in regulating membrane trafficking and organelle structure
  • involved in the structure and function of the Golgi complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    second step in de novo phospholipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS