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FLASH GENE

Symbol

KLRG1

contributors: npt - updated : 09-12-2002

HGNC name	killer cell lectin-like receptor subfamily G, member 1
HGNC id	6380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.2-p13.1      Physical location : 9.142.220 - 9.163.338
Synonym name	mast cell function associated antigen-like
	NK cell antigen 2F1
	ITIM-containing receptor MAFA-L
Synonym symbol(s)	MAFA-2F1, MAFAL, 2F1, CLEC15A, MAFA, MAFA-L, MGC13600

DNA

TYPE	functioning gene
STRUCTURE	21.12 kb     5 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence   long interspersed repetitive elements
text structure	line-1-like element and a (CTT
	170 triplet repeat in intron sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KLRG1 5 - 1815 21.2 189 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol   mast cell Blood/Hematopoietic basophil Blood/Hematopoietic NK cell

cell lineage
cell lines	basophilic leukemia cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	extracytoplasmic carbohydrate recognition domain homolog
	the C type lectin family member, group V, like Ly-49
	a cytoplasmic tail containing an immunoreceptor tyrosine-based inhibition motif (ITIM)
	four potential N-glycosylation sites

HOMOLOGY

interspecies

homolog to murine Klrg1

Homologene

FAMILY	natural killer cell lectin-like receptor
	subfamily G, in the NK (natural killer) complex (NKG2@)

CATEGORY

immunity/defense , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 2 membrane protein

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS