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FLASH GENE

Symbol

KCNG1

contributors: - updated : 02-06-2007

HGNC name	potassium voltage-gated channel, subfamily G, member 1
HGNC id	6248

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13      Physical location : 49.620.193 - 49.639.675
Synonym name	potassium channel KH2
	potassium channel Kv6.1
Synonym symbol(s)	K13, KCNG, KV6.1, MGC12878, kH2

DNA

TYPE	functioning gene
STRUCTURE	19.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 2237 - 513 - Su variant 2 - - 2250 - 275 brain, placenta Su

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate         male system testis       Skin/Tegument skin         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six putative membrane-spanning domains and an hydrophobic pore including the P domain with the K+ channel signature
	TM domains 5 and 6, sensitive to changes in membrane potential

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies

homolog to rattus Ik8

Homologene

FAMILY

potassium channel, voltage-gated, subfamily G

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

basic FUNCTION	may need to associate with another protein to form a
	functional channel
	may modulate channel activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS