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FLASH GENE
Symbol KIR2DS4 contributors: np/ - updated : 10-04-2006
HGNC name killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
HGNC id 6336
Location 19q13.42      Physical location : 55.344.173 - 55.360.023
Synonym name
  • natural killer-associated transcript 8
  • natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS4 (see FLNKR@)
  • CD158 antigen-like family member I
  • P58 natural killer cell receptor clones CL-39/CL-17
  • MHC class I NK cell receptor
  • KIR antigen 2DS4
  • CD158i antigen
    • Synonym symbol(s) NKAT8, KKA3, K2S4, cl-39, CD158i, MGC120019, KIR412, MGC125317
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text natural killer cell receptor cluster FLNKR@
    STRUCTURE 15.85 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text alternatively spliced (truncated) forms (PMID: 8662091)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1586 - 304 - 1996 8662091
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig extracellular domains
  • a short cytoplasmic tail
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • natural killer cell receptors family
    • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • playing a role in recognizing major histocompatibility class I molecules on target cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS