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Symbol CEBPA contributors: mct/npt/pgu - updated : 23-09-2016
HGNC name CCAAT/enhancer binding protein (C/EBP), alpha
HGNC id 1833
Location 19q13.11      Physical location : 33.790.841 - 33.793.430
Synonym symbol(s) CEBP, CEBA, C/EBP-alpha
TYPE functioning gene
STRUCTURE 2.63 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure DNA binding protein, intronless
MAPPING cloned Y linked N status confirmed
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 initiation site 2591 - 358 - 1993 8367486
1 initiation site 2631 30 239 - -
  • also called C/EBP30
  • AUG 351 nt dowstream of the first
  • truncating mutations enhancing the production of a 30kDa C terminal form
  • 1 - 2631 - 393 - -
    1 - 2631 - 344 - -
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     stomach   highly
    Reproductivefemale systemplacenta   
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage only myelomonocytic cells lineage
    cell lines
    at STAGE
    physiological period pregnancy
    Text at highest level in placenta
  • transactivation domains (TADs) at its N-terminus
  • a DNA-binding and dimerization bZIP structure at its C-terminus, with a functional importance which may mediate cooperative activation by CEBPA and GABPA of myeloid-specific genes involved in CEBPA-dependent granulopoiesis
  • mono polymer heteromer , dimer
    interspecies homolog to rattus Cebpa (95.20 pc)
    homolog to murine Cebpa (95.76 pc)
    intraspecies homolog to CEBPG
  • bZIP family
  • C/EBP subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • granulocytic differentiation factor downregulated c-Myc target gene
  • coexpressed with and cross-regulated by PPARG, jointly required for full adipocyte differentiation and for granulocytic differentiation
  • a key regulator of airway epithelial maturation
  • mediating lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes
  • having a necessary role for transcriptional control of granulocyte, adipocyte and hepatocyte differentiation, glucose metabolism and lung development
  • important regulator of cytokine expression in human neutrophils
  • CEBPB, CEBPA and ZFPM1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional antagonism a potential mechanism for separation of the myeloid and Mk/E lineages
  • CEBPA and DEK coordinately activate myeloid gene expression and S21 phosphorylation on wild-type CEBPA mediates protein interactions that regulate the differentiation capacity of hematopoietic progenitors
  • CEBPA and/or GATA1 directly suppress the expression of DACH1 through binding to the promoter region
  • is the key transcriptional regulator of osteoclast (OC) lineage commitment
  • key transcription factor involved in the adipocyte differentiation
  • acts to modulate the epigenetic states of genes belonging to molecular pathways important for hematopoietic stem cells (HSCs) function
  • is required for macrophage activation, which plays an important role in maintaining skeletal muscle energy metabolism
  • CELLULAR PROCESS nucleotide, transcription, regulation
    metabolism energetic
  • energy pathway
  • molecular pathway PTEN-CEBPA-CTNNA1 which is evolutionarily conserved, and controls myeloid development and transformation
  • a component
  • binding to sequence CCAAT enhancer
  • RNA
    small molecule
  • inhibiting SPI1 (PU1) and influencing cell fate and directing the development to the granulocyte lineage
  • binds KLF3 and both are implicated in controlling adipogenesis
  • functional interaction with CDX1 and PPARG
  • (CDX1 enhanced the expression of PPARG, a master transcriptional regulator of intestinal differentiation, at the transcriptional level, via functional interaction with CEBPA)
  • TCERG1 functions as an inhibitor of CEBPA rather than a transcriptional co-repressor, and inhibits CEBPA activity by keeping it retained in inactive, pericentromeric heterochromatin
  • substrate for FBXW7 (FBXW7 is a negative regulator of CEBPA function by targeting it to phosphorylation-dependent degradation)
  • interacting with HDAC9 (induction of adipogenic differentiation promotes HDAC9 down-regulation and replacement by EP300 at the E-box site of the CEBPA gene promoter, thus switching on adipogenic gene expression)
  • PTPN11 is required for induction of CEBPA expression and granulopoiesis in response to G-CSF or other cytokines independent of PTPN11-mediated ERK activation 8)
  • FABP1 is regulated by liver-enriched transcription factors FOXA2 and CEBPA
  • in committed macrophage progenitors, CEBPA-activated QKI negatively regulates macrophage differentiation by down-regulating CSF1R expression, forming a negative feedback loop during macrophage differentiation
  • ATF3 may contribute to the inhibition of adipocyte differentiation in hypoxia through downregulation of CEBPA expression
  • DICER1 might have important roles in the expression of adipogenic genes including PPARG and CEBPA via regulation of the expression of miRNAs at the early, but not the late, stage of adipocyte differentiation
  • TET2 helps CEBPA rapidly derepress myeloid genes during the conversion of pre-B cells into macrophages
  • DDIT3 is necessary for suppression of genes encoding the transcriptional master regulators of lipid metabolism: CEBPA, PPARA, and SREBF1
  • UBE3A may negatively control adipogenesis by inhibiting CEBPA expression by targeting it to ubiquitin-proteasome pathway for degradation
  • RARA-ZBTB16 acts as a modifier oncogene that subverts differentiation in the granulocytic lineage by associating with CEBPA and inhibiting its activity
  • MBD2 colocalizes with the transcription factor CEBPA, and MBD2 binding at these positions is reduced upon CEBPA depletion
  • IKZF1 is a suppressor of basophil differentiation under steady-state conditions and that it acts by regulating permissive chromatin modifications of CEBPA
  • CEBPA interacts with the ETS domain of widely expressed GABPA, which leads to cooperative transcriptional activation of the myeloid-specific promoter for FCAR in part by facilitating recruitment of CEBPA to the promoter
  • CEBPA binding initiates chromatin relaxation and transcription, which are followed by DNA demethylation around a CEBPA binding site and a transcription start site in the AGT promoter
  • plays a dual role as an activator and as a repressor of GNAI2 gene transcription
  • regulatory role of CEBPA on VCAM1 expression
  • dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of CEBPB and CEBPD and direct transcriptional activation of PPARG2 and CEBPA during adipocyte differentiation
  • SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARG, CEBPA and MEST
  • cell & other
    induced by CEBPB and CEBPD
    inhibited by leukemic fusion gene AME
    repressed by BCR-ABL (through inhibitory action of PCBP2)
    ZBTB16 (represses transcription factors involved in normal myeloid differentiation, including GFI1, C/EBPalpha)
    ATF3, that represses CEBPA, resulting in inhibition of adipocyte differentiation, and thus playing a role in hypoxia-mediated inhibition of adipocyte differentiation
    Other regulated by an ERK1/2-mediated change in the conformation of CEBPA that favors monocyte differentiation by blocking granulopoiesis
    regulated by CITED2-TFAP2C complex which controls lung maturation by regulating CEBPA expression
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    212delC associated with familial acute myeloblastic leukemia with good prognostic
    tumoral       loss of function
    or low expressed in acute myeloid leukemia
    tumoral somatic mutation      
    cause a myeloid differentiation block and were detected in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), multiple myeloma and non-Hodgkin's lymphoma (NHL)
    tumoral     --low  
    contributes to MN1-modulated proliferation and impaired myeloid differentiation of hematopoietic cells
    tumoral       loss of function
    SOX4 overexpression resulting from its inactivation contributes to the development of leukemia with a distinct leukemia-initiating cells (LICs) phenotype
    Variant & Polymorphism 212delC associated with familial acute myeloblastic leukemia with good prognostic
    Candidate gene
    Therapy target