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FLASH GENE
Symbol CSDE1 contributors: mct/npt - updated : 24-04-2009
HGNC name cold shock domain containing E1, RNA-binding
HGNC id 29905
Location 1p13.2      Physical location : 115.259.537 - 115.300.671
Synonym name
  • N-Ras (NRAS) upstream expressed sequence
  • upstream of NRAS
  • UNR protein
    • Synonym symbol(s) D1S155E, KIAA0885, UNR, NRU, DKFZp779B0247, DKFZp779J1455, FLJ26882
    DNA
    TYPE functioning gene
    STRUCTURE 41.09 kb     20 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map pter - 5' - P2RY4 - NRAS - 3' - qter
    RNA
    TRANSCRIPTS type messenger
    text multiple transcripts produced by multiple polyadenylation sites and alternative splicing (Jeffers)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4115 88.7 798 - Jeffers (1990)
    - - 4216 90.5 813 - Jeffers (1990)
    19 - 4041 85.6 767 - Jeffers (1990)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus unr
    homolog to murine D3Jfr1
    homolog to Drosophila CG7015
    homolog to Xenopus Xl.4677
    Homologene
    FAMILY
  • cold-shock domain (CSD) family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • required for internal initiation of translation of rhinovirus RNA
  • involved in translational regulation of specific genes
  • playing a role with HNRPC in internal initiation of translation during mitosis
  • internal initiation trans-acting factor (ITAF) in the cap-independent translation of some particular viral and cellular mRNAs (Cornelis 2005)
  • RNA-binding protein involved in the regulation of messenger RNA stability and internal initiation of translation (Dormoy-Raclet 2007)
  • acting as a positive or negative regulator of cell death, depending on the cell type (Dormoy-Raclet 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text male gonad development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to UNRIP
    • cell & other
    REGULATION
    Other developmentally regulated expression in the testis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS