| basic FUNCTION
| acting as a putative growth suppressor that plays an important role in the regulation of cytokine signaling |
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regulating both insulin, leptin signaling and adipocyte leptin production through its neuronal form and probably is essential for the development of leptin resistance |
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playing a potential role in myeloid development, macrophage activation and a physiological role in immune regulation |
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negatively regulating macrophage development through CSF1 signaling |
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reduces the phosphorylation of PRDX4, and contributes to the redox-controlled processes occurring at the ER |
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role of microtubules and cell contacts in the positioning of ER-bound PTPN1 the peripheral region of growth cones, which may be required for the positive role of PTPN1 in axon elongation, filopodia stabilization, and Src activity  |
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implicated in the regulation of the insulin receptor |
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regulates the endosomal sorting machinery |
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can influence RTK signaling in a previously unrecognized manner |
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governs signaling and biological activity of EPHA3 |
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modulator of brown fat adipogenesis, suggesting that adipocyte differentiation requires regulated expression of PTPN1 |
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in POMC neurons plays a role in short-term cold-induced reduction of spontaneous physical activity and may influence cold-induced thermogenesis via enhanced activation of the thyroid axis |
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major regulator of adiposity and insulin sensitivity |
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negative regulator of IR (insulin receptor) activation and glucose homoeostasis |
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may play a critical role in multiple signaling networks involved in oncogenesis |
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modulates early endosome fusion and trafficking of MET and epidermal growth factor receptors |
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key negative regulator of leptin and insulin signaling, is positively correlated with adiposity and contributes to insulin resistance |
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may play an important role in suppressing hepatocarcinogenesis |
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physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress |
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negatively regulates ER stress, as well as insulin and leptin resistance |
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PTPN1 and PTPRJ are required for optimal platelet activation and aggregate formation under high arterial shear rates |
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is capable of binding and dephosphorylating IFNAR1 |
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in addition to modulating FGFR3 phosphorylation, PTPN1 and PTPN2 constrain the kinase domain by fostering an inactive-state |
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controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia |
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