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FLASH GENE
Symbol PTPN1 contributors: mct/ - updated : 28-08-2015
HGNC name protein tyrosine phosphatase, non-receptor type 1
HGNC id 9642
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in chronic myelogenous leukemia
tumoral     --over  
in the mammary gland leads to spontaneous breast cancer development
constitutional       loss of function
deficiency enhances insulin signaling, in skeletal muscle and liver, reduces adiposity
tumoral       loss of function
when PTPN1 activity is inhibited, BCR-ABL is degraded by the ubiquitin lysosomal pathway
tumoral     --low  
significantly associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma (HCC)
Susceptibility to essential hypertension, hypercholesterolemia and obesity (Japanese people)
Variant & Polymorphism SNP increasing the risk of essntial hypertension, hypercholesterolemia and obesity
Candidate gene
Marker
  • may serve as a valuable prognostic biomarker in hepatocellular carcinoma (HCC)
    • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    inhibition of PTP1B may be a useful strategy to explore in the development of novel therapeutic agents for the treatment of chronic myelogenous leukemia
    cancerhemopathy 
    potential target for treating myeloid malignancies
    cancerreproductivebreast
    therapeutic target in breast cancer
    neurosensorialear 
    PTPN1 inhibition may be useful for treating deafness associated with hyperglycemia and type 2 diabetes
    cancerdigestiveliver
    potential therapeutic target in hepatocellular carcinoma (HCC)
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    PTPN1 inhibitor may be used as a potential therapeutic agent against Parkinson's disease
    ANIMAL & CELL MODELS