Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in chronic myelogenous leukemia | tumoral
|  
|  
| --over
|  
|
in the mammary gland leads to spontaneous breast cancer development | constitutional
|  
|  
|  
| loss of function
|
deficiency enhances insulin signaling, in skeletal muscle and liver, reduces adiposity  | tumoral
|  
|  
|  
| loss of function
|
when PTPN1 activity is inhibited, BCR-ABL is degraded by the ubiquitin lysosomal pathway  | tumoral
|  
|  
| --low
|  
|
significantly associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma (HCC)  | |